Correspondence re: M. Follen et al., a randomized clinical trial of 4-hydroxyphenylretinamide for high-grade squamous intraepithelial lesions of the cervix.
نویسنده
چکیده
منابع مشابه
A randomized clinical trial of 4-hydroxyphenylretinamide for high-grade squamous intraepithelial lesions of the cervix.
PURPOSE Previous trials of topical trans-retinoic acid treatment of cervical intraepithelial neoplasia (CIN) grades 2 and 3 led to a statistically significant regression of CIN 2, but not CIN 3. We tested N-(4-hydroxyphenyl)retinamide (4-HPR), a promising oral retinoid that has been shown to induce apoptosis through nonretinoic receptor acid-mediated pathways, for its toxicity and efficacy agai...
متن کاملEffects of biographical variables on cervical fluorescence emission spectra.
Diagnostic algorithms can classify tissue samples as diseased or nondiseased based on fluorescence emission collected from the intact cervix. Such algorithms can distinguish high-grade squamous intraepithelial lesions from low-grade squamous intraepithelial lesions. An understanding of the effects of the values of biographical covariates, such as age, race, smoking, or menopausal status on the ...
متن کاملCorrelation of P16 (Ink4a) and CK17 to HPV (16E6+18E6) in Premalignant and Malignant Lesions of Uterine Cervix: A Clinicopathologic Study
Background: This research was accomplished to evaluate the IHC expression of p16 (ink4a) and CK17 in low grade cervical intraepithelial lesions (LSIL), high grade cervical intraepithelial lesions (HSIL) and invasive cervical carcinomas and to assess their correlation to HPV (16E6+18E6). Methods: The study...
متن کاملWhy most randomized phase II cervical cancer chemoprevention trials are uninformative: lessons for the future.
According to the worldwide cancer incidence database maintained by the World Health Organization, cervical cancer is the third most common malignancy in women worldwide, exceeded in incidence only by breast and colorectal cancers (1). Cervical cancer is an important cause of mortality in women worldwide, and the cervix is a well-established clinical and histopathologic model of carcinogenesis. ...
متن کاملA case - control study of human papillomaviru s and cervical squamous intraepithelial lesions ( SIL ) in
We conducted a case-control study of the association between SIL and HPV among whites (W) , African Americans (AA), and Hispanics (H) in Harris County, Tex a s . Cases were identified at M.D. Anderson Cancer Center Colposcopy Clinic. C o n t rols were identified among women obtaining routine Pap screening at two Harris County Health De p a rtment Clinics. H P V was detected by a PCR-based fluor...
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ورودعنوان ژورنال:
- Clinical cancer research : an official journal of the American Association for Cancer Research
دوره 8 5 شماره
صفحات -
تاریخ انتشار 2002